Human rights are at risk. Issues such as the climate crisis, ongoing conflicts in Europe and beyond, attacks on and the suppression of minorities, rapid technological changes, a war on information and the regression of democracy and the rule of law, just to name a few, challenge and question the effect of human rights. The European Yearbook on Human Rights 2022 aims to identify and address a variety of the most pressing human rights issues in Europe and beyond. Renowned scholars, emerging voices and practitioners, in a careful selection of chapters, contribute to critical and important discussions related to, for example, climate change litigation, human rights and artificial intelligence and the right to open science. Thereby, the Yearbook stimulates necessary discussions, critical thinking and further research in the field and thus contributes to upholding human rights as guiding standards and principles in these tumultuous times.